Promising Cancer Research

by Admin on May 13, 2013

0410_curecancer

Ellagic Acid Research

Over the last 30 years there has been a great deal of information accumulated in the literature concerning the carcinogenic process. It has been established that disruption of the delicate balance between cell growth and programmed cell death (apoptosis) in favor of the former by inhibiting or slowing down the latter, results in tumor formation. There are two apoptotic pathways: a) the so called “stress pathway” or intrinsic pathway which is initiated by profound damage to the DNA by either chemotherapy and/or radiation; and b) the extrinsic pathway which is initiated by binding of specific cytokines released by cells to their so called “death receptors” expressed on cancer cells also following heavy damage of the DNA. The binding of cytokines to their death receptors exposed on the cancer cells will result in programmed cell death. Both apoptotic pathways meet at the caspase level. Caspases are enzymes that initiate and perform apoptosis. There are several big differences between apoptosis in cancer cells and normal cells. A normal cell has a very efficient base excision repair system and any damage to DNA is immediately and efficiently repaired. By definition, a normal cell with irreparable DNA/mutations must undergo apoptosis because of activation of p53 through the intrinsic pathway. Some cells with mutations do not die because they are resistant to apoptosis. These cells become cancer cells. Most of the time, the apoptotic process is inhibited from inside the cell by the inhibitors of apoptosis (IAPs). Normal cells do not have any inhibitors of apoptosis.

Casein kinase 2 (CK2) is a kinase that is important for cell proliferation and is over-expressed in all types of cancer studied thus far. There is an overwhelming amount of data gathered in the literature demonstrating that CK2 is over-expressed in tumor cells and is involved in the apoptosis-resistance phenotype of most malignant cells. The emerging hypothesis is that high concentrations of CK2 generate a cellular environment that is favorable to both the establishment and the development of the tumor phenotype. CK2 is localized in the cytoplasm of normal cells. However, in cancer cells, CK2 is also localized in the nucleus and is deregulated, being elevated 3- to 7- fold. The up-regulation and hyperactivity of CK2 in the nucleus has an anti-apoptotic effect and is correlated with aggressive tumor behavior in a multitude of different cancer cell types examined.

Ellagic acid (abundant in pomegranate and red and black raspberries) has been identified as a very potent CK2 inhibitor. The Ki of ellagic acid for CK2 is 20 nM. It has been shown that ellagic acid alone will kill several cancer cell lines through the apoptotic process. Ellagic acid is found naturally in pomegranate and raspberries and is transformed into urolithins that remains in plasma for a longer time. There are a multitude of publications demonstrating that casein kinase 2 maintains a high concentration of IAPs inside the cancer cells. In contrast, a simple inhibitor of casein kinase 2 will induce cell death through apoptosis in all cancer cells studied thus far, without affecting any other normal cell/tissue.

We determined the content of ellagic acid and derivatives in Meeker Red Raspberry powder and in the Black Raspberry Seed powder. Ellagic acid and its derivatives from the two samples were first separated by high pressure liquid chromatography (HPLC) prior or after acid hydrolysis. It is noteworthy that acid hydrolysis of each powder releases several urolithins which were identified according to their molecular mass. The separated components were identified by mass spectrometry. Each peak was quantified and compared to a standard made of serial dilutions of purified ellagic acid. Under the conditions employed we have determined that the Meeker Red raspberry contains 0.128 ± 0.005 mg of pure ellagic acid per gram of powder, while the Black Raspberry Seed contains 0.38 ± 0.024 mg of pure ellagic acid per gram of powder.

Following acid hydrolysis (2 hrs in 2N HCl, 50% MeOH at 95°C) we have determined that the Meeker Red raspberry powder contains 23.7 ± 8.32 mg of ellagic acid and derivatives per gram of powder while the Black Raspberry Seed powder contains 41 ± 2.1 mg of ellagic acid and derivatives per gram of powder. The powders are usually dispensed orally with a scoop, provided within the container. The scoop contains 19 grams of powder. Under these conditions, two scoops of Meeker Red raspberry powder or of Black Raspberry Seed powder taken orally (and as a consequence subjected to acid hydrolysis in the stomach), will release approximately 1.1 gr and 1.6 gr respectively of ellagic acid and derivatives. In order to maintain a constant amount of ellagic acid and urolithins in the blood stream this procedure should be repeated daily or at least every other day.

Source: Research Cleveland State University

BLACK RASPBERRIESRubus_occidentalis_fruits

“Rubus occidentalis
Rubus occidentalis is a species of Rubus native to eastern North America. Its common name black raspberry is shared with the closely related western American species Rubus leucodermis.”

Health Benefits
Black Raspberries contain an extremely dark pigment which allows them to be used as a colorant and gives black raspberries one of the highest antioxidant ratings in common fruits and berries. Rich in ellagic acid, anthocyanins and antioxidants, black raspberries have been called the “king of berries” for their superior health benefits.

Studies at Ohio State University have found significant decreases in colon tumors in rats and esophageal tumors in mice fed a diet with black raspberries. In vitro studies have shown that extracts of raspberries and blackberries may slow the growth of breast cervical, colon and esophageal cancers. Human clinical trials are underway to assess the effects of black raspberries on colon and esophageal cancers in humans.

  • The king of berries in terms of health benefits.Has an extremely high overall level of phenolic compounds compared to other berries.
  • Phenolic compounds such as ellagic acid, gallic acid and rutin contribute to the health benefits of black raspberries.
  • Contains high levels of anthocyanins, which give them their rich, dark color. Anthocyanins work as antioxidants that help fight free radical damage in the body. The anthocyanin level of black raspberries is 214-589 mg/100g.
  • Antioxidant levels of food is sometimes measured as ORAC (Oxygen Radical Absorption Capacity). The ORAC level of black raspberries is 77 µmoles /TE/g, about three times higher than blueberries, a very powerful antioxidant.
  • Black raspberries are rich in ellagic acid. Ellagic acid is a phenolic compound known to be a potent anticarcinogen, anti-viral and anti-bacterial. The ellagic acid level of black raspberries is 5.37 mg/g of dry weight.
  • University studies are underway to determine black raspberries’ ability to slow the growth of certain cancers. In vitro studies show that extracts of raspberries and blackberries may slow or reverse the growth of breast, cervical, colon, oral and esophageal cancers.
  • Studies at Ohio State University showed a 60–80 % reduction in colon tumors in rats fed a diet with black raspberries added.
  • Studies at Ohio State University showed an 80% reduction in esophageal cancers in mice fed a 5-10% diet of black raspberries.
  • Scientists from Ohio State University are now conducting human clinical trials into the effects of black raspberries on colon and esophageal cancer in humans.
  • Black raspberries continue to generate a high level of interest from research scientists due to their potent antioxidant and anti-cancer properties.
  • Source: Oregon Raspberry & Blackberry Commission

In an effort to thank our loyal customers, we have put together some amazing money-saving packages for you.
raspberries
RED Raspberrygold Combination Pack
INCLUDES:  4 – one pound containers of red Raspberrygold powder
BONUS:          1 additional pound of red Raspberrygold powder ($99.99 value)
COST:  $399.96

black-raspberries
BLACK Raspberrygold Combination Pack
INCLUDES:  3 – 1/2 pound containers of black Raspberrygold powder
BONUS:          1 additional half pound of black Raspberrygold powder ($79.99 value)
COST:  $239.97

Buy BOTH packs and get a FREE bottle of red Raspberrygold capsules ($59.99 value)
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Welcome to Raspberrygold

by Admin on February 26, 2013

How Important is Ellagic Acid?bodyimage

The Medical University of South Carolina considers the findings regarding ellagic acid powerful enough to initiate a study of human, female volunteers infected with the human papilloma virus in their cervix to determine if this will decrease their chance of developing cervical cancer. 

Dr. Nixon’s work at the Medical University of South Carolina’s Hollings Cancer Institute determined that ellagic acid could kill cervical cells infected with the papilloma virus.  It is known that the human papilloma viruses 16 and 18 probably cause most of the cervical cancers treated today.

The information regarding ellagic acid causing death of the cells that may result in cancer has prompted a study of high risk patients for developing colon cancer.  This study is also underway at the Hollings Cancer Institute.  Individuals with intestinal polyps that cause cancer are being given raspberry material to see if this will reduce their chance of cancer.  The initial findings are encouraging, but not yet conclusive.

The University of Colorado will also be conducting a similar study regarding colon cancer prevention.  Many of these studies are funded by grants from the United States government because it is believed that simple ways of reducing cancer rates will result in less expense in treating our aging population.

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